MARK T. GOULET, Ph.D.
Executive Director,
Drug Discovery & Optimization

Dr. Goulet received a B.S. degree in chemistry from the University of Michigan and a Ph.D. in chemistry from Yale University.  He joined Merck in 1987 and worked within the Medicinal Chemistry department at Rahway in the areas of immunoregulation, endocrinology, obesity and atherosclerosis.  In 2004 he moved to Boston to become Head of Chemistry at the opening of this research facility.

Key Publications, 2003 – Present
Goulet, M.T.; Mosley, R.T.  chapter:  “Peptidomimetics”, in Encyclopedia of Hormones, Academic Press, 2003.

Janovick JA, Goulet M, Bush E, Greer J, Wettlaufer DG, Conn PM.
Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor. J Pharmacol Exp Ther. 2003 May;305(2):608-14.

Ujjainwalla F, Warner D, Walsh TF, Wyvratt MJ, Zhou C, Yang L, Kalyani RN, MacNeil T, Van der Ploeg LH, Rosenblum CI, Tang R, Vongs A, Weinberg DH, Goulet MT.
Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4431-5.

Jiang J, DeVita RJ, Goulet MT, Wyvratt MJ, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP.
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1795-8.

DeVita RJ, Parikh M, Jiang J, Fair JA, Young JR, Walsh TF, Goulet MT, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP, Wyvratt MJ.
Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5599-603.

Ujjainwalla F, Warner D, Snedden C, Grisson RD, Walsh TF, Wyvratt MJ, Kalyani RN, Macneil T, Tang R, Weinberg DH, Van der Ploeg L, Goulet MT.
Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: Discovery of the dihydropyridazinone motif. Bioorg Med Chem Lett. 2005 Jul 6.